Protagonist Thomas is brought into a place known as the Glade, with no memories except of his name. He and other teenage boys call themselves Gladers, and have made a community in which each is assigned to a task belonging different departments headed by a Keeper. The Glade is surrounded by a gigantic Maze in which mechanical creatures called Grievers roam at night. Huge doors around the Glade close at sunset. Supplies are brought to the Glade every week; whereas a new boy is sent through an elevator called the Box once every month. The day after Thomas is brought to the Glade, a girl is sent with a message that "this is the last one ever", and carrying a note that no children shall follow. Meanwhile, Thomas learns that the Gladers have tried to solve the Maze for at least three years and that the antidote to a Griever's painful sting can recover one's memories. He also befriends a young Glader named Chuck and the Gladers' second-in-command 'Newt'. Gladers exploring the Maze are known as 'Runners'.
One day the chief Runner Minho reveals to Thomas and the Gladers' leader 'Alby' that he encountered a dead Griever near the Cliffs (an edge of the Maze). The next day, Alby and Minho search for this dead Griever, but Alby is stung by it and Minho struggles to carry him into the Glade. As the doors close against Minho and Alby, Thomas joins them in the Maze. Hearing approaching Grievers, Minho leaves Thomas with an unconscious Alby. Thomas saves Alby; and with Minho, whom he finds, tricks pursuing Grievers into falling off the Cliff. Minho and Thomas return to the Glade as the doors open the next morning. As the acting leader, Newt calls a meeting to decide the fate of Thomas for going without permission, and it is decided that Thomas be made a Runner after serving one day in jail. Minho and Thomas, running the Maze, discover a 'Griever Hole' exposing the outside world. After returning to the Glade, Thomas is shocked to hear the girl speak telepathically to him. He realizes her name is Teresa, and she tells him that she has triggered an 'Ending'. Soon afterwards, Teresa wakes from the coma and befriends Thomas. The same day, the sky becomes a dull grey, and Thomas attributes this to the Creators of the Glade. That night, the Maze's Doors remain open, leaving the Gladers unprotected from the Grievers.
After Alby recovers from the sting, he begins to speak of his renewed memories. During his conversation with Thomas, Alby begins choking himself, and Thomas calls on Newt to stop Alby. When the Grievers enter the Glade, Glader 'Gally' throws himself onto one and the Grievers retreat. It is discovered that all the Runners' Maps of the Maze made by the Runners have been burned; but Newt and Minho reveal that they had hidden the Maps in the Gladers' Weapons Room, and left decoys. Thomas finds a code in the true Maps, but they are all unsure of how to use it. Desperate for answers, Thomas allows himself to be stung by a Griever to use any memories revealed by the antidote. Thus he realizes that the Gladers have been placed in an experimental situation to test their strength, and tells the other Gladers to go down the Griever Hole and enter the code in a computer to escape the Maze. Upon reaching the Hole, they find the Grievers are waiting for them. The Gladers attack the Grievers while Thomas, Teresa, and Chuck reach the computer, where Teresa enters the code while Thomas and Chuck fend off the Grievers. After entering the code, the Grievers are shut down and the remaining Gladers continue. They are greeted by Gally in a hooded robe, brought by a woman in a lab coat. Gally throws a knife at Thomas; but Chuck takes the blow, and dies in Thomas' hands. A group of armed people attack the Creators. The leader of the attackers guides the Gladers to a bus. Before Thomas joins the others, a woman proclaims that Thomas shall "save everyone from the flare", before she is pulled aside and killed. Then the Gladers are taken to a dormitory where they are fed and allowed rest.
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